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KMID : 0370020030170000023
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Chung-Ang Journal of Pharmacal Sciences
2003 Volume.17 No. 0 p.23 ~ p.33
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Evaluation of Antioxidant And anti-inflammatory Potential of Mixed Ethanol Extract from Biofuntional Foods Prescriptions
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Abstract
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To investigate the antioxidant activitys of Biofuntional Foods Prescriptions(BFP), we were measured radical scavenging activity with DPPH method and anti-lipid peroxidative efficacy on human LDL with TBARS assay. The DPPH was revealed that Two BFP have siginificantly antioxidant activity. But, TBARS assay showed that Rx B which was signifacantly antioxidant activity had lower anti-lipid peroxidative efficacy when compared to that of contrast drug, ascorbic acid.
The anti-inflammatory potential of ethanol exracts of Rx B was evaulated against model of inflammation such as carragenin induced paw edema in rats. 100㎎/㎏, 200㎎/㎏, and 400㎎/㎏ fractions of Rx B showed 20.95%, 12.56%. 18.95% when compared to that of control animals at one hour after oral administration. The effect was comparable with that of the standard drug indomethacin, a standard non-steroidal anti-inflammatory drug.
Inhibition rates of each fraction showed a few lower than that of standard drug, indomethacin. At two, three, four hour after oral administration, 100㎎/㎏ fraction showed 26.9.3%, 33.73%, 21.4%, 200㎎/㎏ fraction showed 20.4%, 22.99%, 15.24%, and 400㎎/㎏ fraction showed 21.43%, 21.30%, 10.85%. Inhibition rates of each fractions were significantly reduced when compared to that of the standard drug indomethacin that showed 27.79%, 35.81%, 22.40% at two, three, four hour after oral administration
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